Peptides for Chronic Inflammation & Inflammatory Conditions

How peptide Targets Peptides for Inflammation

Anti-inflammatory peptides work through diverse mechanisms:

**NF-κB suppression (KPV, BPC-157):** NF-κB is the master transcription factor for inflammatory cytokines (IL-1β, IL-6, TNF-α). KPV (alpha-MSH fragment) is one of the most potent NF-κB suppressors identified — it directly blocks the nuclear translocation of the NF-κB complex. BPC-157 also reduces NF-κB-driven inflammation, particularly in the GI tract.

**Immune modulation (Thymosin Alpha-1, LL-37):** Rather than broadly suppressing inflammation, these peptides modulate immune balance — enhancing regulatory T-cell function and shifting from Th1/Th17 inflammatory dominance toward Th2/Treg tolerance. This is particularly relevant for autoimmune-driven inflammation.

**Mitochondrial anti-inflammatory (SS-31, MOTS-c):** Mitochondrial dysfunction drives sterile inflammation through DAMP release and inflammasome activation. SS-31 stabilizes mitochondrial membranes; MOTS-c activates AMPK which suppresses inflammatory signaling. Both address the mitochondrial root of age-related inflammation ('inflammaging').

**Resolution promotion (BPC-157):** Rather than just suppressing initiation, BPC-157 appears to promote the resolution phase of inflammation — the active biological program that clears inflammatory mediators and initiates tissue repair.