Peptides Academy
TB-500 (Thymosin β4 Fragment)
Research-Grade
TB-500 is a synthetic analog of a naturally occurring region of Thymosin β4 (Tβ4) — a 43-amino-acid G-actin sequestering protein expressed in virtually every mammalian cell. The TB-500 fragment retains the actin-binding active site responsible for the most-studied downstream effects of Tβ4: cytoskeletal reorganization, enhanced cellular migration, accelerated re-epithelialization, and upregulation of VEGF-driven angiogenesis. Preclinical and early-clinical research with the full Tβ4 protein has explored corneal wound healing, epidermolysis bullosa, chronic pressure ulcers, and post-MI cardiac repair. The synthetic TB-500 fragment is used in research protocols exploring similar mechanisms at lower cost. Because of its longer biological half-life versus many other regenerative peptides, TB-500 is typically dosed less frequently (every 3–7 days in rodent models) rather than daily.
Specifications
| Origin / Manufacturer | Synthetic |
| Active Components | TB-500 fragmentBacteriostatic water |
| Storage | Lyophilized room-temp; reconstituted 2–8°C |
| Shelf Life | Lyophilized 24+ months |
| Form Factor | Lyophilized powder (2 mg or 5 mg vial) |
Frequently Asked Questions
Sources & References
Every clinical claim on this page traces to a primary peer-reviewed source.
- 1Crockford D. Development of thymosin β4 for treatment of patients with ischemic heart disease. Annals of the New York Academy of Sciences. 2007;1112:385-95. doi:10.1196/annals.1415.051 PMID:17947580
- 2Goldstein AL, Hannappel E, Kleinman HK. Thymosin beta4: actin-sequestering protein moonlights to repair injured tissues. Trends in Molecular Medicine. 2005;11(9):421-9. doi:10.1016/j.molmed.2005.07.004 PMID:16099219
- 3Malinda KM, Sidhu GS, Mani H, et al.. Thymosin beta4 accelerates wound healing. Journal of Investigative Dermatology. 1999;113(3):364-8. PMID:10469331
Reviewed by
Clinical Research Review Board
Pharmacology & Endocrinology Review
All clinical claims cross-checked against primary sources. Read our editorial policy →
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