Peptides Academy
BPC-157
Research-Grade
BPC-157 (Body Protection Compound 157) is a pentadecapeptide sequence derived from a larger protective protein identified in human gastric juice. Across a wide body of rodent studies it has demonstrated accelerated healing across multiple tissue types — tendon, ligament, muscle, bone, skin, and gastrointestinal mucosa — with an unusually broad mechanism that appears to involve upregulation of growth-hormone receptor expression, modulation of the nitric-oxide system, and enhanced angiogenesis via VEGFR2 activation. Human clinical data remains limited; regulatory status varies by jurisdiction and it is classified as a research peptide in most countries. In animal injury models BPC-157 has shortened tendon-to-bone healing times, reduced inflammatory cytokines after muscle crush injury, and protected against NSAID-induced GI lesions. Its apparent stability in gastric acid has made oral and subcutaneous routes both plausible delivery methods in preclinical work.
Specifications
| Origin / Manufacturer | Synthetic |
| Active Components | BPC-157 pentadecapeptideBacteriostatic water (for reconstitution) |
| Storage | Lyophilized: room temperature. Reconstituted: 2–8°C |
| Shelf Life | Lyophilized 24+ months; reconstituted 30 days refrigerated |
| Form Factor | Lyophilized powder (5 mg or 10 mg vial) |
Frequently Asked Questions
Sources & References
Every clinical claim on this page traces to a primary peer-reviewed source.
- 1Sikiric P, et al.. Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract. Current Pharmaceutical Design. 2010;16(10):1224-34. PMID:20388081
- 2Chang CH, Tsai WC, Hsu YH, Pang JH. Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts. Molecules. 2014;19(11):19066-77. doi:10.3390/molecules191119066 PMID:25415472
- 3Seiwerth S, Rucman R, Turkovic B, et al.. BPC 157 and Standard Angiogenic Growth Factors. Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing. Current Pharmaceutical Design. 2018;24(18):1972-1989. PMID:29879879
- 4Huang T, Zhang K, Sun L, et al.. Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro. Drug Design, Development and Therapy. 2015;9:2485-99. doi:10.2147/DDDT.S82030 PMID:25995620
Reviewed by
Clinical Research Review Board
Pharmacology & Endocrinology Review
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