The Peptide Tier List

Not a vibe ranking. Every tier below is anchored to evidence quality — phase-3 trial data, reproducible preclinical effect sizes, and safety signals. The gap between "works in mice and forums" and "works in a controlled human trial" is enormous; we use it as the spine of this list.

Methodology note — this list weights published phase-2/3 trial data most heavily, followed by reproducible preclinical data, then mechanism plausibility. Internet popularity, influencer endorsement, and anecdote are not inputs. Updated when meaningful trial readouts publish.