Peptides Academy
MOTS-c
Research-Grade
MOTS-c (Mitochondrial Open Reading-frame of the Twelve S ribosomal RNA type-c) is a mitochondrially-encoded peptide identified in 2015. It belongs to the emerging mitokine class — signaling molecules synthesized inside mitochondria that exert systemic effects. Preclinical research has centered on AMPK pathway activation, enhanced skeletal-muscle glucose uptake, improved insulin sensitivity in high-fat-diet rodent models, and extended healthspan in aged mice. MOTS-c expression declines with age in human tissues, paralleling declines in mitochondrial function, and exogenous administration in mice has attenuated age-associated metabolic dysfunction. Human data remains extremely limited; it is classified as a research peptide worldwide.
Specifications
| Origin / Manufacturer | Synthetic (endogenous homolog) |
| Active Components | MOTS-c |
| Storage | Lyophilized room-temp; reconstituted 2–8°C |
| Form Factor | Lyophilized powder vial |
Sources & References
Every clinical claim on this page traces to a primary peer-reviewed source.
- 1Lee C, Zeng J, Drew BG, et al.. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism. 2015;21(3):443-54. doi:10.1016/j.cmet.2015.02.009 PMID:25738459
- 2Reynolds JC, Lai RW, Woodhead JST, et al.. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature Communications. 2021;12:470. doi:10.1038/s41467-020-20790-0 PMID:33473109
Reviewed by
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Pharmacology & Endocrinology Review
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