Peptides AcademyNiacinamide (Vitamin B3)
How to Use
Niacinamide is compatible with virtually all peptide families, retinoids, and other actives. The historical caution about combining niacinamide with vitamin C has been debunked — modern formulations are stable together.
With peptides
Fully compatible. Apply niacinamide serum, then peptide serum, or use a product containing both. Many multi-peptide serums include niacinamide (e.g., The Ordinary Buffet).
With retinol
Complementary. Niacinamide's barrier-strengthening effect helps mitigate retinoid irritation. Apply niacinamide first, retinol on top.
With vitamin C
Safe to combine despite older advice. The concern about niacin conversion is negligible at physiological skin pH and modern ingredient purity.
Best For
Where this entry is most relevant.
anti-aging
Stimulates ceramide and fatty acid synthesis in the stratum corneum, strengthening the barrier that retains moisture and protects collagen from environmental damage.
skin-glow
Inhibits melanosome transfer from melanocytes to keratinocytes, reducing hyperpigmentation and evening skin tone over 8-12 weeks.
What is it?
A water-soluble vitamin that strengthens the skin barrier, reduces inflammation, regulates sebum production, and fades hyperpigmentation. One of the most versatile and well-tolerated actives in skincare — and a frequent companion to peptide formulations.
How It Works
- 1
NAD+ precursor activity
Niacinamide is converted to NAD+ (nicotinamide adenine dinucleotide) in cells, fueling energy metabolism and supporting DNA repair enzymes (PARP, sirtuins).
- 2
Ceramide synthesis upregulation
Increases synthesis of ceramides, cholesterol, and fatty acids in the stratum corneum, strengthening the lipid barrier and reducing transepidermal water loss (TEWL).
- 3
Melanosome transfer inhibition
Blocks the transfer of melanin-containing melanosomes from melanocytes to surrounding keratinocytes, reducing visible pigmentation without affecting melanin production itself.
- 4
Anti-inflammatory signaling
Suppresses NF-κB activation and reduces IL-6, IL-8, and TNF-α production, calming redness and inflammation — particularly beneficial for rosacea and acne-prone skin.
Role
Barrier strengthener, anti-inflammatory, pigment regulator
Evidence
Multiple RCTs demonstrate efficacy at 2-5% for barrier improvement, pigment reduction, and sebum regulation. A 2004 study (Bissett et al., Dermatologic Surgery) showed 5% niacinamide reduced fine lines, hyperpigmentation, and yellowing over 12 weeks vs. vehicle. Well-tolerated even in sensitive skin types.
Common Formats
How this shows up in practice.
The Ordinary Niacinamide 10% + Zinc 1%
Serum
High-concentration; may cause irritation in some users at 10%
CeraVe PM Facial Moisturizing Lotion
Moisturizer
4% niacinamide with ceramides — excellent peptide-routine companion
Paula's Choice 10% Niacinamide Booster
Booster serum
Mixable with other serums including peptide products