Peptides Academy
MGF (Mechano Growth Factor)
Research-Grade
Mechano Growth Factor (MGF) is an alternatively spliced isoform of IGF-1 that is expressed locally in response to mechanical stress or tissue damage, particularly in skeletal muscle. Unlike systemic IGF-1Ea, which circulates and acts broadly, MGF (IGF-1Ec in humans, IGF-1Eb in rodents) acts in an autocrine/paracrine fashion to activate muscle satellite cells — the resident stem cell population responsible for post-exercise and post-injury muscle repair. The synthetic peptide form corresponds to the unique C-terminal extension of the MGF splice variant. In preclinical studies, local MGF injection has increased satellite cell activation, accelerated muscle hypertrophy following damage, and improved functional recovery in muscle injury models. PEGylated MGF (PEG-MGF) was developed to extend the short biological half-life. Human clinical trials are absent; use is currently limited to research contexts.
Specifications
| Origin / Manufacturer | Synthetic |
| Active Components | MGF peptide (E-domain)Bacteriostatic water (for reconstitution) |
| Storage | Lyophilized: -20°C to 4°C. Reconstituted: 2–8°C |
| Shelf Life | Lyophilized 18+ months; reconstituted 7–14 days refrigerated |
| Form Factor | Lyophilized powder (2 mg or 5 mg vial) |
Frequently Asked Questions
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