5-Amino-1MQ

Research-Grade

5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme overexpressed in obese adipose tissue and aged skeletal muscle. NNMT inhibition is theorized to divert methyl groups back toward productive cellular methylation reactions, increase NAD+ availability, and improve metabolic function. Preclinical data is encouraging: mice on high-fat diets show significant weight reduction, improved insulin sensitivity, and reduced adipose expansion with 5-Amino-1MQ treatment. Muscle-regeneration studies in aged mice have reported improved stem-cell function and faster recovery. Human data is essentially absent. The molecule is frequently marketed and discussed alongside peptides in fat-loss contexts, but strictly speaking it is a small molecule, not a peptide. It is included here for completeness.