DSIP (Delta Sleep-Inducing Peptide)

Research-Grade

DSIP (delta sleep-inducing peptide) is a nonapeptide originally isolated from the cerebral venous blood of rabbits during electrically-induced sleep. Its native physiological role remains incompletely defined. Published investigations have reported increases in slow-wave (delta) sleep, modulation of the HPA axis under stress, and attenuation of opioid withdrawal symptoms in small cohorts. Clinical development has been slow. Most published human data is from 1980s-90s European investigations using intravenous DSIP for chronic insomnia, pain syndromes, and opioid detoxification. Reported effects on sleep architecture have not been consistently replicated in modern polysomnographic studies. Oral bioavailability is negligible; intranasal and subcutaneous routes are used off-label.