Peptides Academy
Kisspeptin-10
Research-Grade
Kisspeptin-10 (KP-10) is the minimally active C-terminal decapeptide of kisspeptin-54, the endogenous ligand of the KISS1R (GPR54) receptor. Kisspeptin neurons in the arcuate and anteroventral periventricular nuclei of the hypothalamus are the upstream regulators of GnRH pulsatility — they are the hormonal 'master switch' that initiates puberty, maintains reproductive cyclicity, and integrates metabolic signals with reproductive function. Kisspeptin-10 has been administered IV in over a dozen human studies at Imperial College London and other centers. At low doses it robustly stimulates LH and FSH secretion within minutes, making it a precise diagnostic probe of hypothalamic-pituitary-gonadal axis integrity. At higher or repeated doses, it has been studied as a potential fertility treatment, particularly for triggering oocyte maturation in IVF with substantially lower ovarian hyperstimulation risk compared to hCG triggers. Beyond reproduction, kisspeptin signaling intersects with metabolic regulation: KISS1R is expressed in pancreatic beta cells and adipose tissue, and kisspeptin administration affects insulin secretion and psychosexual arousal in human studies.
Specifications
| Origin / Manufacturer | Synthetic |
| Active Components | Kisspeptin-10 acetateMannitol (lyoprotectant) |
| Storage | Lyophilized: −20°C. Reconstituted: 2–8°C |
| Shelf Life | Lyophilized 12+ months; reconstituted 7–14 days refrigerated |
| Form Factor | Lyophilized powder (research vial) |
Clinical Evidence
Clinical report reference
Clinical report reference
Clinical report reference
Clinical report reference
Frequently Asked Questions
Sources & References
Every clinical claim on this page traces to a primary peer-reviewed source.
- 1Dhillo WS, Chaudhri OB, Patterson M, et al.. Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males. Journal of Clinical Endocrinology & Metabolism. 2005;90(12):6609-6615. doi:10.1210/jc.2005-1468 PMID:16174713
- 2Jayasena CN, Abbara A, Comninos AN, et al.. Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization. Journal of Clinical Investigation. 2014;124(8):3667-3677. doi:10.1172/JCI75730 PMID:25036713
- 3Comninos AN, Wall MB, Demetriou L, et al.. Kisspeptin modulates sexual and emotional brain processing in humans. Journal of Clinical Investigation. 2017;127(2):709-719. doi:10.1172/JCI89519 PMID:28112679
Reviewed by
Clinical Research Review Board
Reproductive Endocrinology Review
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