Matrixyl 3000 vs. Matrixyl synthe'6 — what's the difference?

Different Sederma peptide blends targeting different collagen pathways. Matrixyl 3000 (palmitoyl tripeptide-1 + tetrapeptide-7) has the longer clinical track record. Matrixyl synthe'6 (palmitoyl tripeptide-38) was developed later with a broader protein-synthesis profile. Stacking both is the rationale of this formulation.

Will this irritate like retinol?

No. Palmitoyl peptides have no known irritation mechanism — no photosensitivity, no purge, no pH conflict. Side-effect profile is one of the strongest arguments for peptides vs. retinoids.

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Matrixyl 10% + HA

Name: Matrixyl 10% + HA
Brand: The Ordinary
Price: 14.90 USD
Availability: InStock

The Ordinary

Matrixyl 10% + HA stacks two Sederma peptide technologies: Matrixyl 3000 (palmitoyl tripeptide-1 + palmitoyl tetrapeptide-7) and Matrixyl synthe'6 (palmitoyl tripeptide-38). The combination targets distinct collagen-signaling pathways. Clinical data on Matrixyl 3000 shows 15-30% wrinkle-depth reduction over 8-12 weeks of twice-daily use. The HA backbone provides immediate surface hydration so the serum doesn't leave the typical peptide 'tight-feel' residue. Because palmitoyl peptides are fatty-acid-tailed, they penetrate the stratum corneum better than raw peptides — the engineering reason this class has held up through formulation scrutiny.

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Peptides in this product

Matrixyl 3000 (Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7)

10% (supplier blend)

Collagen I/III signaling

Targets

Peptides for Anti-Aging

Key ingredients

Palmitoyl Tripeptide-1Palmitoyl Tetrapeptide-7Palmitoyl Tripeptide-38Sodium Hyaluronate

How to use

Apply AM and/or PM on clean skin before heavier creams. Safe to layer with retinol, niacinamide, AHAs, and vitamin C. Full wrinkle-depth effect is 8-12 weeks of consistent use.