Peptides Academy
Matrixyl 3000 (Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7)
Various (Topical Cosmetic)
Matrixyl 3000 is a combination of palmitoyl tripeptide-1 (formerly Matrixyl, mimicking a pro-collagen I fragment) and palmitoyl tetrapeptide-7 (derived from a GHK-adjacent sequence). The palmitoyl fatty-acid tail on each peptide provides the lipophilicity needed to cross the stratum corneum — a key engineering point for any topical peptide. Clinical evidence includes reductions in wrinkle depth (typically 15-30% vs placebo over 2 months of twice-daily application), improvement in skin firmness markers, and modest collagen synthesis upregulation documented in biopsy studies. Effect sizes are smaller than topical retinoids but the side-effect profile is substantially milder — no photosensitivity, no irritation-dependent dosing, no purge period. Matrixyl 3000 is commonly layered with niacinamide, vitamin C, or retinol routines. Formulation concentration matters: effective products contain 5-10% Matrixyl 3000 (by Sederma's supplier specification, this corresponds to 0.05-0.1% of the active peptide). Lower concentrations are common in mass-market products.
Source references
Specifications
| Origin / Manufacturer | Synthetic (INCI-listed) |
| Form Factor | Serum, cream, or ampoule |
Frequently Asked Questions
Sources & References
Every clinical claim on this page traces to a primary peer-reviewed source.
- 1Robinson LR, Fitzgerald NC, Doughty DG, et al.. Topical palmitoyl pentapeptide provides improved connective tissue support. Journal of Cosmetic Dermatology. 2005;4:305-14. PMID:17168876
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Consumer products featuring Matrixyl 3000 (Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7)
All skincare →Finished serums, creams, and treatments that contain Matrixyl 3000 (Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7). Links go to retailers; we may earn a commission.
Liquid Peptides
Medik8
Medik8's flagship multi-peptide serum with Argireline, copper peptides, and a signal-peptide complex in a lightweight fluid.
$70-90
Regenerist Micro-Sculpting Cream
Olay
Drugstore mass-market peptide moisturizer with palmitoyl pentapeptide-4, niacinamide, and amino-peptide complex. The accessibility benchmark for peptide skincare.
$28-38
Peptide Booster
Paula's Choice
Concentrated multi-peptide booster designed to layer under any serum or moisturizer. Contains Matrixyl 3000, palmitoyl tripeptide-38, and acetyl hexapeptide-8.
$45-55
High Potency Classics: Eye Lift
Perricone MD
Peptide-forward eye treatment targeting dark circles, puffiness, and crow's feet with palmitoyl tetrapeptide-7 and proprietary DMAE complex.
$65-78
Peptide 21 Wrinkle Resist Serum
Peter Thomas Roth
Peptide-forward anti-aging serum featuring 21 peptides and neuropeptides alongside squalane and hyaluronic acid, positioned as a premium Argireline-plus alternative.
$90-105
TL Advanced Tightening Neck Cream Plus
StriVectin
Neck and décolletage peptide cream featuring Gravitite-CF Lifting Complex, NIA-114 technology, and a collagen-boosting peptide blend.
$85-105
Buffet + Copper Peptides 1%
The Ordinary
Multi-peptide serum combining Matrixyl 3000, Argireline, SYN-AKE, Relistase, and 1% Copper Peptides (GHK-Cu) in a single formulation.
$28-32
Matrixyl 10% + HA
The Ordinary
Dual-Matrixyl serum combining Matrixyl 3000 and Matrixyl synthe'6 at the supplier-recommended 10% each, boosted with hyaluronic acid.
$14-18