Matrixyl 3000 (Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7)
Various (Topical Cosmetic)
Matrixyl 3000 is a combination of palmitoyl tripeptide-1 (formerly Matrixyl, mimicking a pro-collagen I fragment) and palmitoyl tetrapeptide-7 (derived from a GHK-adjacent sequence). The palmitoyl fatty-acid tail on each peptide provides the lipophilicity needed to cross the stratum corneum — a key engineering point for any topical peptide. Clinical evidence includes reductions in wrinkle depth (typically 15-30% vs placebo over 2 months of twice-daily application), improvement in skin firmness markers, and modest collagen synthesis upregulation documented in biopsy studies. Effect sizes are smaller than topical retinoids but the side-effect profile is substantially milder — no photosensitivity, no irritation-dependent dosing, no purge period. Matrixyl 3000 is commonly layered with niacinamide, vitamin C, or retinol routines. Formulation concentration matters: effective products contain 5-10% Matrixyl 3000 (by Sederma's supplier specification, this corresponds to 0.05-0.1% of the active peptide). Lower concentrations are common in mass-market products.
Source references
Specifications
| Origin / Manufacturer | Synthetic (INCI-listed) |
| Form Factor | Serum, cream, or ampoule |
Frequently Asked Questions
Sources & References
Every clinical claim on this page traces to a primary peer-reviewed source.
- 1Robinson LR, Fitzgerald NC, Doughty DG, et al.. Topical palmitoyl pentapeptide provides improved connective tissue support. Journal of Cosmetic Dermatology. 2005;4:305-14. PMID:17168876
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Consumer products featuring Matrixyl 3000 (Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7)
All skincare →Finished serums, creams, and treatments that contain Matrixyl 3000 (Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7). Links go to retailers; we may earn a commission.

Skin Renewing Cream Serum
CeraVe
Affordable ceramide-peptide serum combining a three-peptide complex with CeraVe's MVE ceramide delivery technology for barrier-supportive anti-aging at drugstore pricing.
$18-24

Charlotte's Magic Cream
Charlotte Tilbury
Luxury multi-peptide moisturizer with BioNymph peptide complex, Vitamin C, and hyaluronic acid — designed as a skincare-makeup hybrid that primes, hydrates, and firms.
$75-100

Peptide Complex Serum with Matrixyl 3000 & Argireline
Cos De BAHA
Budget-friendly K-beauty serum combining Matrixyl 3000 and Argireline in a single formula — the two most evidence-backed cosmetic peptides at an accessible price point.
$12-16
Advanced Retinol + Ferulic Overnight Texture Renewal Peel
Dr. Dennis Gross
A retinol-peptide hybrid peel combining encapsulated retinol with bakuchiol and peptides — targeting texture, fine lines, and tone in a single overnight treatment.
$82-92

Pro-Collagen Marine Cream SPF 30
Elemis
Award-winning anti-aging moisturizer combining Palmitoyl Tripeptide-1 and marine actives (Padina Pavonica algae, Chlorella) with broad-spectrum SPF 30 for daily photoprotection.
$89-105
Peptide Moisturizer
Good Molecules
Budget-friendly peptide moisturizer combining Matrixyl 3000, Matrixyl Synthe'6, and Argireline in a lightweight cream — one of the best value multi-peptide moisturizers available.
$12-15
+Retinol Vita C Peptide K8 Power Cream
Kate Somerville
A premium anti-aging moisturizer combining eight peptides with retinol and vitamin C in a rich cream format, targeting fine lines, firmness, and radiance simultaneously.
$98-120

Retinol B3 Serum
La Roche-Posay
Retinol serum formulated with peptides, niacinamide (B3), and hyaluronic acid — designed for anti-aging on sensitive skin types.
$40-48

Liquid Peptides
Medik8
Medik8's flagship multi-peptide serum with Argireline, copper peptides, and a signal-peptide complex in a lightweight fluid.
$70-90

Rapid Wrinkle Repair Retinol + Peptide Multi-Action Serum
Neutrogena
Drugstore-accessible serum combining retinol SA with a multi-peptide complex for wrinkle reduction, firmness, and even skin tone.
$18-25
Laboratories Line Correcting Booster Serum
No7
A UK pharmacy brand serum powered by Matrixyl 3000+ at a clinically tested concentration, delivering visible wrinkle reduction backed by independent clinical trials.
$35-45

Regenerist Micro-Sculpting Cream
Olay
Drugstore mass-market peptide moisturizer with palmitoyl pentapeptide-4, niacinamide, and amino-peptide complex. The accessibility benchmark for peptide skincare.
$28-38

Peptide Booster
Paula's Choice
Concentrated multi-peptide booster designed to layer under any serum or moisturizer. Contains Matrixyl 3000, palmitoyl tripeptide-38, and acetyl hexapeptide-8.
$45-55

High Potency Classics: Eye Lift
Perricone MD
Peptide-forward eye treatment targeting dark circles, puffiness, and crow's feet with palmitoyl tetrapeptide-7 and proprietary DMAE complex.
$65-78

Peptide 21 Wrinkle Resist Serum
Peter Thomas Roth
Peptide-forward anti-aging serum featuring 21 peptides and neuropeptides alongside squalane and hyaluronic acid, positioned as a premium Argireline-plus alternative.
$90-105

Revox 7
Revision Skincare
Clinical-grade peptide serum with seven targeted peptides for expression lines, including Argireline (Acetyl Hexapeptide-8) and multiple collagen-stimulating signal peptides.
$110-130

TNS Advanced+ Serum
SkinMedica
Professional-grade growth factor and peptide serum featuring SkinMedica's proprietary TNS-MR (fibroblast conditioned media) plus a multi-peptide blend for comprehensive anti-aging.
$295-350

TL Advanced Tightening Neck Cream Plus
StriVectin
Neck and décolletage peptide cream featuring Gravitite-CF Lifting Complex, NIA-114 technology, and a collagen-boosting peptide blend.
$85-105

Buffet + Copper Peptides 1%
The Ordinary
Multi-peptide serum combining Matrixyl 3000, Argireline, SYN-AKE, Relistase, and 1% Copper Peptides (GHK-Cu) in a single formulation.
$28-32

Buffet Multi-Technology Peptide Serum
The Ordinary
The Ordinary's flagship multi-peptide serum — Matrixyl 3000, Matrixyl Synthe'6, SYN-AKE, Argirelox, and SNAP-8 in a single hyaluronic acid base for broad-spectrum anti-aging.
$17-20

Matrixyl 10% + HA
The Ordinary
Dual-Matrixyl serum combining Matrixyl 3000 and Matrixyl synthe'6 at the supplier-recommended 10% each, boosted with hyaluronic acid.
$14-18
Stroke of Brilliance Brightening Serum
Versed
Clean-beauty brightening serum combining vitamin C derivative, niacinamide, and peptides for radiance and even tone — available at Target for under $20.
$18-22