Skip to content
New: free dose calculator with 14 peptide presets. No signup.
Peptides Academy
Matrixyl 3000 (Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7)
Topical Peptides

Matrixyl 3000 (Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7)

Various (Topical Cosmetic)

Matrixyl 3000 is a combination of palmitoyl tripeptide-1 (formerly Matrixyl, mimicking a pro-collagen I fragment) and palmitoyl tetrapeptide-7 (derived from a GHK-adjacent sequence). The palmitoyl fatty-acid tail on each peptide provides the lipophilicity needed to cross the stratum corneum — a key engineering point for any topical peptide. Clinical evidence includes reductions in wrinkle depth (typically 15-30% vs placebo over 2 months of twice-daily application), improvement in skin firmness markers, and modest collagen synthesis upregulation documented in biopsy studies. Effect sizes are smaller than topical retinoids but the side-effect profile is substantially milder — no photosensitivity, no irritation-dependent dosing, no purge period. Matrixyl 3000 is commonly layered with niacinamide, vitamin C, or retinol routines. Formulation concentration matters: effective products contain 5-10% Matrixyl 3000 (by Sederma's supplier specification, this corresponds to 0.05-0.1% of the active peptide). Lower concentrations are common in mass-market products.

Source references

Specifications

Origin / ManufacturerSynthetic (INCI-listed)
Form FactorSerum, cream, or ampoule

Frequently Asked Questions

Sources & References

Every clinical claim on this page traces to a primary peer-reviewed source.

  1. 1Robinson LR, Fitzgerald NC, Doughty DG, et al.. Topical palmitoyl pentapeptide provides improved connective tissue support. Journal of Cosmetic Dermatology. 2005;4:305-14. PMID:17168876

Reviewed by

Clinical Research Review Board

Pharmacology & Endocrinology Review

All clinical claims cross-checked against primary sources. Read our editorial policy →

Consumer products featuring Matrixyl 3000 (Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7)

Finished serums, creams, and treatments that contain Matrixyl 3000 (Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7). Links go to retailers; we may earn a commission.

Skin Renewing Cream Serum
serum

Skin Renewing Cream Serum

CeraVe

Affordable ceramide-peptide serum combining a three-peptide complex with CeraVe's MVE ceramide delivery technology for barrier-supportive anti-aging at drugstore pricing.

$18-24

matrixyl-3000
Charlotte's Magic Cream
cream

Charlotte's Magic Cream

Charlotte Tilbury

Luxury multi-peptide moisturizer with BioNymph peptide complex, Vitamin C, and hyaluronic acid — designed as a skincare-makeup hybrid that primes, hydrates, and firms.

$75-100

matrixyl-3000
Peptide Complex Serum with Matrixyl 3000 & Argireline
serum

Peptide Complex Serum with Matrixyl 3000 & Argireline

Cos De BAHA

Budget-friendly K-beauty serum combining Matrixyl 3000 and Argireline in a single formula — the two most evidence-backed cosmetic peptides at an accessible price point.

$12-16

matrixyl-3000argireline
serum

Advanced Retinol + Ferulic Overnight Texture Renewal Peel

Dr. Dennis Gross

A retinol-peptide hybrid peel combining encapsulated retinol with bakuchiol and peptides — targeting texture, fine lines, and tone in a single overnight treatment.

$82-92

matrixyl-3000
Pro-Collagen Marine Cream SPF 30
cream

Pro-Collagen Marine Cream SPF 30

Elemis

Award-winning anti-aging moisturizer combining Palmitoyl Tripeptide-1 and marine actives (Padina Pavonica algae, Chlorella) with broad-spectrum SPF 30 for daily photoprotection.

$89-105

matrixyl-3000
cream

Peptide Moisturizer

Good Molecules

Budget-friendly peptide moisturizer combining Matrixyl 3000, Matrixyl Synthe'6, and Argireline in a lightweight cream — one of the best value multi-peptide moisturizers available.

$12-15

matrixyl-3000argireline
cream

+Retinol Vita C Peptide K8 Power Cream

Kate Somerville

A premium anti-aging moisturizer combining eight peptides with retinol and vitamin C in a rich cream format, targeting fine lines, firmness, and radiance simultaneously.

$98-120

matrixyl-3000argireline
Retinol B3 Serum
serum

Retinol B3 Serum

La Roche-Posay

Retinol serum formulated with peptides, niacinamide (B3), and hyaluronic acid — designed for anti-aging on sensitive skin types.

$40-48

matrixyl-3000
Liquid Peptides
serum

Liquid Peptides

Medik8

Medik8's flagship multi-peptide serum with Argireline, copper peptides, and a signal-peptide complex in a lightweight fluid.

$70-90

argirelineghk-cumatrixyl-3000
Rapid Wrinkle Repair Retinol + Peptide Multi-Action Serum
serum

Rapid Wrinkle Repair Retinol + Peptide Multi-Action Serum

Neutrogena

Drugstore-accessible serum combining retinol SA with a multi-peptide complex for wrinkle reduction, firmness, and even skin tone.

$18-25

matrixyl-3000
serum

Laboratories Line Correcting Booster Serum

No7

A UK pharmacy brand serum powered by Matrixyl 3000+ at a clinically tested concentration, delivering visible wrinkle reduction backed by independent clinical trials.

$35-45

matrixyl-3000
Regenerist Micro-Sculpting Cream
cream

Regenerist Micro-Sculpting Cream

Olay

Drugstore mass-market peptide moisturizer with palmitoyl pentapeptide-4, niacinamide, and amino-peptide complex. The accessibility benchmark for peptide skincare.

$28-38

matrixyl-3000
Peptide Booster
serum

Peptide Booster

Paula's Choice

Concentrated multi-peptide booster designed to layer under any serum or moisturizer. Contains Matrixyl 3000, palmitoyl tripeptide-38, and acetyl hexapeptide-8.

$45-55

argirelinematrixyl-3000
High Potency Classics: Eye Lift
eye cream

High Potency Classics: Eye Lift

Perricone MD

Peptide-forward eye treatment targeting dark circles, puffiness, and crow's feet with palmitoyl tetrapeptide-7 and proprietary DMAE complex.

$65-78

matrixyl-3000argireline
Peptide 21 Wrinkle Resist Serum
serum

Peptide 21 Wrinkle Resist Serum

Peter Thomas Roth

Peptide-forward anti-aging serum featuring 21 peptides and neuropeptides alongside squalane and hyaluronic acid, positioned as a premium Argireline-plus alternative.

$90-105

argirelinematrixyl-3000ghk-cu
Revox 7
serum

Revox 7

Revision Skincare

Clinical-grade peptide serum with seven targeted peptides for expression lines, including Argireline (Acetyl Hexapeptide-8) and multiple collagen-stimulating signal peptides.

$110-130

argirelinematrixyl-3000
TNS Advanced+ Serum
serum

TNS Advanced+ Serum

SkinMedica

Professional-grade growth factor and peptide serum featuring SkinMedica's proprietary TNS-MR (fibroblast conditioned media) plus a multi-peptide blend for comprehensive anti-aging.

$295-350

argirelinematrixyl-3000
TL Advanced Tightening Neck Cream Plus
cream

TL Advanced Tightening Neck Cream Plus

StriVectin

Neck and décolletage peptide cream featuring Gravitite-CF Lifting Complex, NIA-114 technology, and a collagen-boosting peptide blend.

$85-105

argirelinematrixyl-3000
Buffet + Copper Peptides 1%
serum

Buffet + Copper Peptides 1%

The Ordinary

Multi-peptide serum combining Matrixyl 3000, Argireline, SYN-AKE, Relistase, and 1% Copper Peptides (GHK-Cu) in a single formulation.

$28-32

ghk-cumatrixyl-3000argireline
Buffet Multi-Technology Peptide Serum
serum

Buffet Multi-Technology Peptide Serum

The Ordinary

The Ordinary's flagship multi-peptide serum — Matrixyl 3000, Matrixyl Synthe'6, SYN-AKE, Argirelox, and SNAP-8 in a single hyaluronic acid base for broad-spectrum anti-aging.

$17-20

matrixyl-3000snap-8argireline
Matrixyl 10% + HA
serum

Matrixyl 10% + HA

The Ordinary

Dual-Matrixyl serum combining Matrixyl 3000 and Matrixyl synthe'6 at the supplier-recommended 10% each, boosted with hyaluronic acid.

$14-18

matrixyl-3000
serum

Stroke of Brilliance Brightening Serum

Versed

Clean-beauty brightening serum combining vitamin C derivative, niacinamide, and peptides for radiance and even tone — available at Target for under $20.

$18-22

matrixyl-3000
Reviewed by Clinical Research Review BoardPharmacology & Endocrinology Review

Search

Search across products, blog posts, wiki articles, and more.