Cognitive & Nootropic Peptide Reference

A seven-amino-acid fragment of adrenocorticotropic hormone with cognitive-enhancing properties independent of adrenal stimulation, studied for attention, memory, and learning enhancement in both animal and human trials.

A bovine cerebral cortex-derived neuropeptide complex used clinically in Russia and CIS countries for stroke recovery, traumatic brain injury, and cognitive decline in aging populations.

A porcine brain-derived peptide preparation containing low-molecular-weight neuropeptides and free amino acids, approved in over 40 countries for stroke recovery and traumatic brain injury.

A tetrapeptide bioregulator (Ala-Glu-Asp-Gly) studied for cerebral cortex regulation, neuroprotection after ischemia, and potential cognitive benefits in aging populations.

An investigational eight-amino-acid neuroprotective peptide derived from activity-dependent neuroprotective protein (ADNP) that stabilizes microtubules; studied in tauopathies and cognition with mixed clinical results, now revisited for ADNP-related disorders.

A hexapeptide analog of angiotensin IV that crosses the blood-brain barrier and promotes synaptogenesis via hepatocyte growth factor (HGF) signaling — studied for cognitive enhancement and neurodegenerative disease.

A naturally occurring tripeptide cleaved from the N-terminus of IGF-1 in the brain, studied as a neuroprotective agent in stroke and neurodegeneration models.

An N-acetylated, amidated analog of Selank with improved metabolic stability and enhanced CNS bioavailability — studied for anxiolytic and nootropic effects.

A small peptide fragment derived from ciliary neurotrophic factor (CNTF) that promotes neurogenesis and enhances cognitive function in animal models by crossing the blood-brain barrier.

PE-22-28 is a seven-amino-acid fragment of spadin that blocks the TREK-1 potassium channel. In mouse studies from one research group it had antidepressant-like effects within days; it has never been tested in humans and is an unapproved research chemical.

A synthetic tripeptide (Glu-Asp-Arg, EDR) from the Khavinson bioregulator family, studied for neuroprotection mainly in cell and rodent experiments. Research-only and not FDA-approved; human data are limited to small Russian studies.

A synthetic heptapeptide analog of the endogenous peptide tuftsin, studied in Russia as an anxiolytic. Human data come from small Russian trials; in the US it is a research-only compound.

A synthetic heptapeptide analog of ACTH(4-10) developed in Russia as a nootropic and studied there in ischemic stroke. Human data are small Russian studies; in the US it is a research-only compound.