Peptides Academy
Palmitoyl Tetrapeptide-7
Cosmetic-Grade
Palmitoyl Tetrapeptide-7 (formerly Palmitoyl Tetrapeptide-3) is a short-chain lipopeptide consisting of four amino acids (Gly-Gln-Pro-Arg) conjugated to a palmitoyl fatty acid chain. The palmitoyl lipid tail enhances skin penetration through the stratum corneum, allowing the peptide to reach the dermal layer where it exerts anti-inflammatory effects. Its primary mechanism is suppression of interleukin-6 (IL-6) and related pro-inflammatory cytokines, reducing chronic low-grade inflammation (inflammaging) that accelerates collagen breakdown and skin aging. It also inhibits the secretion of glycation-related damage mediators. Most commonly found as half of the Matrixyl 3000 complex — paired with Palmitoyl Oligopeptide — where it provides the anti-inflammatory component while its partner stimulates collagen synthesis.
Specifications
| Origin / Manufacturer | Synthetic |
| Active Components | Palmitoyl Tetrapeptide-7 |
| Storage | Room temperature; protect from light and moisture |
| Form Factor | Cosmetic raw material or finished serum |
Frequently Asked Questions
Sources & References
Every clinical claim on this page traces to a primary peer-reviewed source.
- 1Lintner K, Peschard O. Biologically active peptides: from a laboratory bench curiosity to a functional skin care product. International Journal of Cosmetic Science. 2000;22(3):207-218. PMID:18503475
- 2Robinson LR, Fitzgerald NC, Pappas DG, et al.. Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin. International Journal of Cosmetic Science. 2005;27(3):155-160. PMID:18492182
Reviewed by
Clinical Research Review Board
Dermatology Review
All clinical claims cross-checked against primary sources. Read our editorial policy →
Consumer products featuring Palmitoyl Tetrapeptide-7
All skincare →Finished serums, creams, and treatments that contain Palmitoyl Tetrapeptide-7. Links go to retailers; we may earn a commission.
Peptide Lip Treatment
Dermalogica
A peptide-infused lip balm with Palmitoyl Tripeptide-38 and hyaluronic acid to plump lip lines and improve lip volume without injection.
$45-52
Tripeptide-R Neck Repair
SkinCeuticals
A premium neck cream combining a proprietary biomimetic tripeptide concentrate with 0.2% retinol — targeting crepey skin, neck lines, and loss of firmness.
$95-115
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Matrixyl 3000 (Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7)
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A well-studied topical peptide combination marketed for wrinkle reduction — the palmitoyl lipid tail enables penetration past the stratum corneum.